However, the results of a review study conducted by Goyal showed that vitamin B6 did not affect the treatment of mastalgia ( 15). Moreover, in a study by Soltany and Alavy Toussy it was found that vitamin B6 reduced the prevalence and the mean pain severity in periodic and non-periodic mastalgia, especially in periodic mastalgia (P < 0.01) ( 14). aiming to study the clinical effectiveness of vitamin B6 and vitamin E on decreasing periodic mastalgia, the trend of changes in mastalgia severity showed a significant reduction in the two groups after the intervention (P < 0.001) ( 6). there was no evidence of the effect of EPO on the treatment of mastalgia ( 13).Īnother medicine that is recommended for the treatment of mastalgia is vitamin B6. on the effect of Vitagnus and Evening primrose on periodic mastalgia compared with vitamin E showed that EPO had fewer effects ( 12). However, the study results of Salehi et al. in Iran on periodic mastalgia, it was found that EPO is able to reduce periodic mastalgia (P < 0.001) ( 11). EPO is rich in essential fatty acids and contains gamma-linolenic acid (GLA) as much as 7% - 14%, which is preventing the synthesis of prostaglandins that potentially cause the breast pain ( 10). The results of a review study by Murshid indicate the effectiveness of evening primrose oil (EPO) for the treatment of cyclical mastalgia ( 1). Today, herbal and nutritional supplements are often suggested as alternative treatments for women with moderate to severe breast pain ( 8). Mastalgia medical treatments mostly include medicines with many side effects and low effectiveness, which limit the use of them ( 6). In addition, various studies have shown the relationship between mastalgia and psychological symptoms such as depression and anxiety ( 2, 9). Joyce reports the prevalence of mastalgia in women as about 57% ( 9). Cyclical mastalgia interferes with sexual (48%), physical (37%), social (12%), occupational and educational (8%) activities and behaviors ( 2, 7, 8). In addition, fibrocystic breast changes can conceal true breast cancer ( 3- 6). Some evidence suggests that women with fibrocystic breast changes and women with mastalgia have a higher risk of breast cancer. The concern causes excessive consumption of sedative medicines without a prescription, as well as inappropriate intervention, excessive mammograms, and undesirable, ineffective, and unnecessary self-treatment. Mastalgia causes concern and fear of breast cancer and has negative effects on quality of life ( 2). The cyclic breast pain (mastalgia) is the most common symptom of fibrocystic breast changes ( 1). The fibrocystic breast changes are one of the most common benign lesions, which cause suffering to women. Mastodynia Evening Primrose Oil Vitamin B6 1. Because of the low cost and more availability of vitamin B6 compared to EPO, it can be used in the first line of treatment. The results of this study showed that vitamin B6 and EPO have the same therapeutic effects in the treatment of cyclic mastalgia.
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